Work

Network toxicology and multiomics reveal bisphenol A-mediated immune evasion in breast cancer

Year: 2025

Type: article

Abstract: Objective To test whether exposure to bisphenol A is related to immune modulation and prognosis in breast cancer using an integrative framework. Methods Bisphenol A targets from toxicology resources were intersected with breast cancer genes. Protein–protein interaction networks were constructed, and hubs were prioritized by centrality. Survival was evaluated in The Cancer Genome Atlas breast cancer cohort using Cox and Kaplan–Meier analyses. The tumor microenvironment was profiled using ESTIMATE scores and CIBERSORT deconvolution. Consistency was examined in the independent METABRIC cohort. Docking was used to estimate bisphenol A–protein binding free energies. Results Filtering converged on four immunoregulatory genes— CCL19 , CD40LG , IGLL5 , and KLRB1 —linked to T cell activation and cytokine signaling. Their expression correlated with the levels of CD8+ T cells, memory B cells, and macrophages. Higher expression predicted improved overall survival in The Cancer Genome Atlas and showed consistent trends in METABRIC. Docking yielded negative free energies compatible with interference in immune signaling. Conclusions This integrative analysis connected environmental toxicology to tumor immunity and nominated CCL19, CD40LG, IGLL5, and KLRB1 as candidate biomarkers for exposure–risk assessment. The findings are correlative and require mechanistic validation.

Source: Journal of International Medical Research

DOI: 10.1177/03000605251395475

Authors: Yu Fang, Jia-Li Yan, Wang Zhang

Institutions: Third People's Hospital of Hefei, Hangzhou Xiaoshan Second People's Hospital

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,155