Work

TfOH-Promoted Cascade Reaction of Nitriles and 1,5-Enynes: An Efficient Route to Amido-Functionalized Fluorenes

Year: 2025

Type: article

Abstract: We have demonstrated a highly efficient synthetic strategy for assembling amide-functionalized fluorenes via cascade reactions between nitriles and 1,5-enynes in a one-pot assembly. This approach provides a simple, atom-economic, practical, and robust path to synthesize highly versatile rare carbocyclic scaffolds under transition-metal- and additive-free conditions with good reaction yields. Its most noteworthy features include high compatibility with various functionalities, mild conditions, easily accessible precursors, and gram-scale synthesis.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02263

Authors: Babasaheb Sopan Gore, Wan-Jing Liu, Lin-Wei Pan, Chien-Hung Li, Jeh-Jeng Wang

Institutions: Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Kaohsiung Medical University, National Science and Technology Council