Mycobacterium abscessus complex infection is associated with poor treatment outcome
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim This study aimed to evaluate the factors associated with poor outcomes and the impact of Mycobacterium abscessus complex (MABC) infection in patients with pulmonary mycobacteriosis in Brazil.Methods This retrospective longitudinal study evaluated risk factors for death, treatment failure, or treatment default using multivariable logistic regression, and analyzed survival using Kaplan – Meier method.Results MABC was identified as a major predictor of unfavorable results. The Kaplan-Meier analysis revealed that patients with MABC infection had a significantly lower probability of a successful outcome compared to those with other nontuberculous mycobacteria (NTM) species (p < 0.01), especially due to a considerably higher rate of treatment failure (p < 0.01). The multivariable regression confirmed that infection by MABC (OR 1.16, 95% CI 1.09–1.23), HIV infection (OR 1.13, 95% CI 1.05–1.21), having only 1 to 3 years of schooling (OR 1.17, 95% CI 1.08–1.26), renal disease (OR 1.32, 95% CI 1.08–1.62), alcohol abuse (OR 1.14, 95% CI 1.03–1.26), and illicit drug use (OR 1.21, 95% CI 1.03–1.41) were independent risk factors for a poor outcome.Conclusion The evidence shows that pulmonary infection by MABC, HIV co-infection, fewer years of schooling, renal disease, alcohol abuse and the use of illicit drugs are associated with poor outcomes.
Source: Future Microbiology
Institution: Universidade Estadual de Maringá
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4417271124