Exploring Nanoherbal Paraboea leuserensis as a Therapeutic Agent in Traumatic Brain Injury: In Silico, and In Vivo Approaches.
Year: 2025
Type: article
Abstract: Background: approaches in a rat model of TBI. Methods: study, 30 male Wistar rats were allocated into six groups: G0 (normal control), G+(TBI control), MP (TBI+methylprednisolone 30 mg/Kg BW), and treatment groups PL100, PL200, and PL300 (TBI+nanoherbal extract at 100, 200, and 300 mg/Kg BW, respectively). Antioxidant activity was evaluated through superoxide dismutase (SOD) and malondialdehyde (MDA) assays. Data were analyzed by one-way ANOVA with Tukey's post hoc test (P<0.05) using GraphPad Prism. Results: , PL100 (P<0.01), PL200 (P<0.001), and PL300 (P<0.0001) significantly enhanced SOD activity and reduced MDA levels compared to the TBI control. Conclusion: , with PL300 showing the most pronounced antioxidant effect in TBI-induced rats.
Source: PubMed
Institutions: Universitas Sumatera Utara, Universiti Putra Malaysia
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4417273764
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