Hypoglycemic mechanism of modified Gegen Qinlian decoction based on regulating the expression and DNA methylation of cholesterol transporters in the adipose tissue of type 2 diabetes mellitus rats.
Year: 2025
Type: article
Abstract: OBJECTIVE: To investigate the hypoglycemic mechanism of modified Gegen Qinlian decoction (，MGQD) by examining its regulation of cholesterol transporter expression and DNA methylation, specifically the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type 1 (SR-B1), in epididymal white adipose tissue (eWAT) and inguinal white adipose tissue (iWAT) of rats with type 2 diabetes mellitus (T2DM). METHODS: (gene encoding SR-B1). RESULTS: in iWAT. CONCLUSIONS: methylation, which may suppress its expression and consequently reduce cholesterol efflux.
Source: PubMed
Authors: Peng Shuhong, Yang Lingkun, Liu Xinyi, Zhang Mengyu, Lin Seqi, Zhang Changhua, X U Guoliang, Zhu Weifeng, Yao Pengcheng
Institution: Jiangxi University of Traditional Chinese Medicine
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4417274209
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