TMEM205 promotes cisplatin resistance in triple-negative breast cancer and induces TAM/M2 polarization
Year: 2025
Type: article
Abstract: Transmembrane protein 205 (TMEM205) is aberrantly expressed in various tumors and is closely associated with cisplatin (DDP) resistance. However, its role in tumor progression and drug resistance in triple-negative breast cancer (TNBC) remains unclear. This study systematically investigates the regulatory function of TMEM205 in DDP-resistant TNBC and explores the underlying molecular mechanisms through a series of in vitro and in vivo experiments. Ours results demonstrate that TMEM205 promotes biological functions in TNBC cells by activating the Wnt/β-catenin signaling pathway, which subsequently induces tumor-associated macrophage (TAM)/M2 polarization, thereby promoting DDP resistance. These findings suggest that TMEM205 may serve as a potential therapeutic target for managing DDP-resistant TNBC, offering novel strategies and insights for the treatment of TNBC.
Source: International Immunopharmacology
Authors: Xia Wang, Hongshu Li, Jiafeng Li, Tiefeng Jin, Meihua Zhang
Institutions: Yanbian University, Yanbian University Hospital
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,220
Awards: G2973375188, G3988131412
OpenAlex ID: W4417274286