Electroacupuncture alleviates type 2 diabetes mellitus by promoting plasma-derived exosomal circular RNA of enhancer of zeste homolog 1 expression.
Year: 2025
Type: article
Abstract: OBJECTIVE: To investigate the effect of electroacupuncture (EA) on regulatory functions of one specific exosomal circRNA of Enhancer of Zeste Homolog (CircEZH) and its potential mechanisms of action in type 2 diabetes (T2DM). METHODS: . RESULTS: , CircEZH1-knockout T2DM mice displayed damaged insulin sensitivity, which was demonstrated by elevated levels of fasting blood glucose and decreased glucose tolerance in the GTT and insulin sensitivity in the ITT. CONCLUSIONS: EA can affect CircEZH1 expression specifically in the exosomes in β cells in the pancreatic islets to improve T2DM. Exosomal CircEZH1 is a potential therapeutic candidate to treat T2DM.
Source: PubMed
Authors: Shou Yin, Jiang Juntao, H U Jianlin, J I Wei, Chen Chunyan, H U Li, M A Yuhang, Zhang Bimeng
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Wellcome Trust
OpenAlex ID: W4417274338