Work

Molecular life sciences in the era of the Fourth Industrial Revolution: sequencing, multi-omics and artificial intelligence

Year: 2025

Type: article

Abstract: The onset of the Fourth Industrial Revolution has catalysed a fundamental shift in how research within the molecular life sciences is approached and undertaken. Over the past decade, a multitude of nascent enabling technologies have progressed to maturity and have become irreversibly embedded in laboratory practice. Artificial intelligence (AI) has become a mainstay within the molecular sciences, facilitating major advances across a multitude of sub-disciplines, including synthetic biology, industrial biotechnology and drug discovery. One area where this impact is being particularly felt is within multi-omics, where the marriage of AI with low-cost high-throughput sequencing is delivering unprecedented advances, allowing large and often complex datasets to be deconvoluted on timescales previously considered unimaginable. In this mini-review, we outline how the integration of AI into multi-omics has been realised and forecast future trajectories for research in this important area.

Source: Emerging Topics in Life Sciences

DOI: 10.1042/etls20253019

Authors: Lee Keenan, R. Lorna Younger, Paul R. Race, Matt Bawn

Institution: Newcastle University

Language: English

Topic: Bioinformatics and Genomic Networks

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Newcastle University, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council

Awards: Unlocking the potential of engineered C-C bond forming enzymes for biocatalysis, G5667755715, G5794767039, Harnessing the Power of Diels-Alderases in Sustainable Chemoenzymatic Synthesis