Work

Novel Substituted Aryl Sulfonamides and Sulfuric Diamides As Transglutaminase 2 Inhibitors

Year: 2025

Type: editorial

Abstract: This patent describes novel substituted aryl sulfonamides and sulfuric diamides as potent transglutaminase 2 (TG2) inhibitors. It provides details on the novel substituted aryl sulfonamide and sulfuric diamide compounds, pharmaceutical formulations, and the use of such compounds in the treatment of TG2-related diseases, such as fibrosis, neurodegenerative diseases, autoimmune diseases, and cancers.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00693

Authors: Jian Rong, Steven H. Liang

Institutions: Emory University, Wuhan Union Hospital, Huazhong University of Science and Technology, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Blood properties and coagulation

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4417280109

Cites: 6

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