Work

Microscale maps of bursting dynamics across human hippocampal slices from patients with epilepsy

Year: 2025

Type: article

Abstract: We apply high-density CMOS-based microelectrode arrays to excised patient brain slices, mapping the communication patterns of hundreds of neurons at unprecedented resolution. We developed novel computational techniques to spatially map neuronal dynamics. In patient slices, our findings suggest that recurrent feedback localized within the dentate gyrus of the hippocampus is linked to a previously unreported phenomenon of theta propagations. This bridges microscale circuit dynamics with alterations in theta oscillations.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00217.2025

Authors: Matthew A. T. Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solís, Edward F. Chang, Tomasz Jan Nowakowski, Mircea Teodorescu, David Haussler, Tal Sharf

Institutions: University of California, Santa Cruz, University of California, San Francisco, University of California, Santa Barbara, University of Washington

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Schmidt Futures, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G1754555162, Machine Learning Augmented Discovery of AAV Capsids for Cell Type Specific Access into Human Neurons and Glia, G502022855, IRACDA at UCSC and CSUMB, Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions., UCSC Graduate Program in Genome Sciences, Developmental Timing During Cortical Development, Center for Live Cell Genomics

OpenAlex ID: W4417283914

FWCI: 0.548

Cites: 67

Cited by: 1

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