Work

RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice

Year: 2025

Type: article

Abstract: Roux-en-Y gastric bypass in obese mice triggered markers of vagal nerve injury, reduced Glp1r-expressing vagal afferents, and lowered Glp1r mRNA in the nodose ganglion. Nerve injury experiments reproduced these effects. Despite reduced receptor expression, GLP1R agonist-evoked vagal firing was exaggerated after RYGB or vagal injury. Overall, the findings indicate RYGB causes vagal neuropathy with diminished Glp1r expression but heightened GLP1 sensitivity.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00452.2025

Authors: Warda Merchant, Arely Tinajero, Adan Khan, Yi Chu, Sanaz Saleh, Dana Tasabehji, Donald A. Morgan, Kevin W. Williams, Kamal Rahmouni, Mohamad Mokadem, Laurent Gautron

Institutions: The University of Texas Southwestern Medical Center, University of Iowa, United States Department of Veterans Affairs, Veterans Health Administration, Iowa City VA Health Care System

Language: English

Topic: Bariatric Surgery and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, University of Texas System, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1728527416, G3196387476, G4095804471, G4717900042, CNS Mechanisms Linking Exercise Training with Energy Balance and Metabolism, Neuronal Cilia in Hypertension, Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated Hypertension, UT Southwestern NORC, Decoding Bariatric Surgery Outcomes through Activity and Transcriptional Analysis of Melanocortin Neurons

OpenAlex ID: W4417284176

FWCI: 4.319

Cites: 83

Cited by: 5

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