Long-term immune and epigenetic dysregulation following COVID-19
Year: 2025
Type: article
Study design: Observational Study
Abstract: ) were upregulated in PACS patients. Respiratory phenotype was correlated with IL-1 upregulation (OR 4.23; 95 % CIs, 1.69-10.8, p = 0.0025). Transcriptomic and epigenomic changes were observed. Distinct phenotypes of PACS are driven by different immunological mechanisms at the DNA, transcriptomic, and protein levels.
Source: Clinical Immunology
Authors: Chrysanthi Sidiropoulou, Garyphallia Poulakou, Evdoxia Kyriazopoulou, Elisavet Tasouli, Efthymia Giannitsioti, Anna Strikou, Maria Tsilika, Eirini Christaki, Vassiliki Rapti, Vassiliki Evangelopoulou, Nikoletta Rovina, Nathalie Iannotti, Emanuele Nicastri, Eleonora Taddei, Helena Florou, Andrea Angheben, Matteo Bassetti, Lorenzo Dagna, Antonio Torres, Spyros Foutadakis, George Adamis, Emmanouil Stylianakis, Giannis Vatsellas, Georgia Damoraki, Leda Efstratiou, Christina Damoulari, Konstantinos Leventogiannis, Achilleas Laskaratos, Panagiotis Koufargyris, Nikoletta Charalampaki, Paraskevi Chra, Aglaia Galanopoulou, Dimitris Thanos, Periklis Panagopoulos, Konstantinos Syrigos, Athanasios Ziogas, Rob ter Horst, Jos W.M. van der Meer, Konstantina Iliopoulou, Francesco Saverio Serino, Maria Pavlaki, Pierluigi Del Vecchio, Laura Scorzolini, Alessandra Bandera, Agamemnon Bakakos, Styliani Sympardi, Haralampos Milionis, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis
Institutions: Tzaneion General Hospital, National and Kapodistrian University of Athens, Thriasio General Hospital of Elefsina, Laiko General Hospital of Athens, Andreas Sygros Hospital, Hellenic Institute for the Study of Sepsis, University of Ioannina, Sotiria General Hospital, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Ospedale Sacro Cuore Don Calabria, Ospedale Policlinico San Martino, University of Genoa, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, General Hospital of Athens G. Genimatas, Academy of Athens, Biomedical Research Foundation of the Academy of Athens, Democritus University of Thrace, Radboud University Nijmegen, University of Bonn
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,400
OpenAlex ID: W4417290574