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Outside Front Cover: An Orthogonal Nucleic Acid/Peptide Amplification Circuit Enables Protease‐Triggered, Cancer Cell‐Selective PD‐L1 Imaging (Angew. Chem. Int. Ed. 4/2026)

Year: 2025

Type: article

Abstract: In the Research Article (e20284), Jian Zhao, Lele Li, and co-workers report an orthogonal hybrid circuit though PNA-directed engineering of DNA signal amplification technology with cleavable peptides, enabling cancer cell-selective PD-L1 imaging via aptamer-mediated recognition of membrane protein and protease-triggered hybridization chain reaction.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.2025-m0512060700

Authors: Bo Wu, Xiulin Yi, Jian Zhao, Lele Li

Institutions: National Center for Nanoscience and Technology, University of Chinese Academy of Sciences

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4417290756

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