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Outside Front Cover: Regulating Promiscuous Catalysis via Substrate‐Induced Transient Assembly (Angew. Chem. Int. Ed. 1/2026)

Year: 2025

Type: article

Abstract: Transient substrate-induced co-assembly between a lysine-rich peptide and Fmoc-glycine is reported in the Communication (e202511352) by David Y.W. Ng, Tanja Weil, and co-workers. The non-equilibrium nanostructure creates a reactive microenvironment enabling promiscuous amino-acid-driven hydrolysis and C═N condensation reactions. Cleavage of the labile Fmoc group triggers collapse of the assembly, illustrating how broad prebiotic catalysis could have emerged under kinetic control.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.2025-m0512055500

Authors: Ayan Chatterjee, Maximilian Schuler, Marius G. Braun, Christopher V. Synatschke, Qi Lu, Jiyao Yu, David Y.W. Ng, Tanja Weil

Institutions: Max Planck Institute for Polymer Research, Max Planck School Matter to Life

Language: English

Topic: Origins and Evolution of Life

Subfield: Astronomy and Astrophysics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4417290953

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