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Macrophage Subtypes in Dermatological Diseases: Implications for Pathogenesis and Therapy

Year: 2025

Type: article

Abstract: Macrophages (Ms) are essential innate immune cells that play a crucial role in maintaining tissue homeostasis and defending against infection. They exhibit significant heterogeneity and plasticity, enabling differentiation into various subtypes in response to distinct microenvironmental cues. Recent advances have illuminated the roles of classically activated (M1) and alternatively activated (M2) types and other specialized macrophage subpopulations in inflammatory skin diseases, wound healing, autoimmune disorders, and other dermatological conditions. Targeting key molecules or markers involved in macrophage subtype differentiation—such as STAT3, STAT6, and CD163—offers promising therapeutic opportunities for the treatment of dermatological diseases.

Source: International Journal of Dermatology and Venereology

DOI: 10.1097/jd9.0000000000000436

Authors: Fang Li, Yang Luo, Xu Yao

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Chinese Academy of Medical Sciences Dermatology Hospital

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4417293380

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