Low levels of systemic inflammation in asymptomatic TB detected during community-based screening in rural South Africa
Year: 2025
Type: preprint
Study design: Observational Study
Abstract: ABSTRACT Asymptomatic TB represents half of prevalent TB yet frequently remains undetected. We assessed the performance of plasma IL-6 and CRP as diagnostic biomarkers for asymptomatic TB identified by community-based screening. Both proteins were elevated in asymptomatic TB compared to community controls, but neither performed well as a diagnostic biomarker.
Source: medRxiv
Institutions: Africa Health Research Institute, Hasso Plattner Institute, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité – Universitätsmedizin Berlin, London School of Hygiene & Tropical Medicine, University College London, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, University of KwaZulu-Natal, University of Alabama at Birmingham
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Africa Health Research Institute NPC - To identify biomarkers across the spectrum of subclinical tuberculosis in humans to help understand how to deploy TB interventions most effectively..., G3466330743, G3696529418, G580663542, G6496233500, G7320554875, Africa Health Research Institute - Core Renewal 2023-30 (GBP), Africa Health Research Institute NPC - to provide support for innovative projects in HIV and TB prevention by an African-led consortium
OpenAlex ID: W4417293381