Hepatitis B Surface Antibody Clearance After Vaccination in People With HIV
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background People with HIV (PWH) are at higher risk of developing chronic hepatitis B, and therefore vaccination against HBV is highly recommended. Clearance of hepatitis B surface antibody (anti-HBs) over time is poorly described in PWH. Methods We retrospectively included vaccinated PWH with anti-HBs ≥10 IU/L from the French Dat’AIDS database. Those with a cured hepatitis B were excluded. For each participant, all anti-HBs levels were collected until March 2024. Anti-HBs peak was defined as the highest anti-HBs value and corresponded to entry into the analysis. Factors associated with anti-HBs clearance below 10 IU/L were identified using a multivariable Cox model. Results 11 082 PWH were included, 4480 had peak anti-HBs levels between 10 and 99 IU/L, 3268 between 100 and 499 IU/L, 1205 between 500 and 999 IU/L, and 2129 ≥ 1000 IU/L. Median follow-up was 3.8 [1.6, 7.1] years. Antibody clearance over time was similar in the three groups with peak anti-HBs ≥100 IU/L, and significantly slower than in the group with anti-HBs <100 IU/L. Peak anti-HBs level was the variable with the greatest impact on anti-HBs clearance in the multivariable analysis. Compared with participants with anti-HBs <100 IU/L, having peak anti-HBs values of 100–499 IU/L, 500–999 IU/L and ≥1000 IU/L were protective factors for anti-HBs clearance, with hazard ratios of .26 [0.23, 0.30], 0.17 [0.13, 0.22] and 0.10 [0.07, 0.12], respectively, P < .001. Conclusions Peak anti-HBs level is the key factor of antibody persistence in PWH. Those with anti-HBs levels below 100 IU/L should be monitored closely and considered for a booster dose.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofaf754
Authors: Axel Ursenbach, François Séverac, Archia Chahard, Dulce Alfaiate, Firouzé Bani-Sadr, Laurent Hocqueloux, David Rey, the Dat’AIDS study group, C Chirouze, K Bouiller, F Bozon, A S Brunel, L Hustache-Mathieu, J Lagoutte, Q Lepiller, S Marty-Quinternet, L Pépin-Puget, B Rosolen, N Tissot, C Lebreton, L Bohard, S Jaffuel, S Ansart, Y Quintric, S Rezig, L Quaesaet, P Gazeau, C Jacomet, N Mrozek, C Theis, M Vidal, C Richaud, V Corbin, A Benelhadj, A Zaghdoudi, C Aumeran, O Baud, M Berthommier, M Charles, C Durand, D Coban, A Mirand, A Brebion, H Chabrolles, O Perruche, E Creuzet, C Henquell, I Lamaury, G Baronnet, F Bissuel, F Boulard, A Chéret, J Coussement, E Curlier, T Dequidt, C Desfontaines, S Devatine, E Duvallon, I Fabre, C Herrmann-Storck, C Loraux, S Markowicz, M Marquet, R Ouissa, S Peugny, L Pradat-Paz, M C Receveur, J Reltien, K Samar, K Schepers, B Tressieres, V Walte, D Merrien, O Bollangier, D Boucher, T Guimard, L Laine, S Leautez, M Morrier, P Perré, M Roncato-Saberan, X Pouget-Abadie, C Chapuzet, A Thomas, J F Faucher, A Cypierre, S Ducroix-Roubertou, H Durox, C Genet-Villeger, J Pascual, P Pinet, C Codde, S Rogez, J B Woillard, C Benoist, S Mafi, D Alfaiate, A Becker, M Godinot, F Ader, E Braun, C Brochier, F Brunel-Dalmas, P Chiarello, A Conrad, S Degroodt, P Fascia, T Ferry, V Gueripel, V Icard, J Izard, C Javaux, H Lardot, J Lippmann, D Makhloufi, Y Merad, T Perpoint, S Roux, S Sahyouni, M Simon, M A Trabaud, C Triffault-Fillit, F Valour, A S Batalla, L Van den Bogaart, A Ménard, Y Belkhir, P Colson, C Dhiver, M Martin-Degioanni, A Motte, C Toméi, M Million, N De Palmas, M Champeaux, I Ravaux, S Brégigeon, O Zaegel-Faucher, H Laroche, M J Ducassou, A Ivanova, I Jaquet, V Obry-Roguet, M Orticoni, E Ressiot, A S Ritleng, F Niemetzky, C Ferron, A Cabié, S Abel, O Cabras, L Cuzin, G Dos Santos, L Facelina, L Fagour, L de Ghellinck, K Guitteaud, E Louis-Michel, E Medo, F Quenard, S Pierre-François, P Richard, A Schapira, B Tregan, C Robert, Z Cavalli, L Bucy, C Emilie, A Fournier, A Makinson, A Artiaga, M Bistoquet, E Delaporte, V Le Moing, J Lejeune, N Meftah, C Merle de Boever, B Montes, L Perez, N Pansu, J Reynes, C Tramoni, E Tuaillon, B Lefèvre, M André, S Bevilacqua, L Boyer, M P Grandin, A Charmillon, M Delestan, E Frentiu, F Goehringer, S Hénard, E Jeanmaire, C Rabaud, L Lalevée, J Kotzyba, C Allavena, E André-Garnier, A Asquier-Khati, V Bellon, E Billaud, C Biron, B Bonnet, S Bouchez, D Boutoille, C Brunet-Cartier, M Cavellec, L Collias, C Deschanvres, T Drumel, B J Gaborit, M Gregoire, T Jovelin, M Lefebvre, R Lecomte, R Mahot, C Mear-Passard, P Morineau, C Moyon, E Paredes, G Querne, A Soria, P Pugliese, S Bréaud, M Buscot, M Carles, D Chirio, J Courjon, E Cua, P Dellamonica, E Demonchy, A De Monte, J Durant, S Ferrando, A Naqvi, I Perbost, C Pradier, B Prouvost-Keller, K Risso, I Touitou, A Viot, S Wehrlen-Pugliese, S Sunder, V Goudet, A Dos Santos, V Rzepecki, L Hocqueloux, R Albert, V Avettand-Fènoël, S Bafong-Ketchemen, G Béraud, J Effa, C Gubavu, V Legros, G Mchantaf, C Mille, Y Mohamed-Kassim, T Prazuck, A Sève, L Vitry d’Aubigny, C Goujard, A Castro-Gordon, P David-Chevallier, V Godard, Y Quertainmont, E Teicher, S Jaureguiberry, L Escaut, M Cresta, B Henry, E Oliosi, C Couzigou, O Derradji, R Collarino, Y Liotier, M Merad, E Zamparini, J Bottero, V Joly, C Charpentier, D Descamps, M Digumber, A Gervais, J Ghosn, Z Julia, R Landman, S Lariven, S Le Gac, F Louni, N Peiffer-Smadja, G Peytavin, C Rioux, Y Yazdanpanah, L Deconinck, C Duvivier, K Amazzough, G Benabdelmoumen, P Bossi, G Cessot, P H Consigny, M Garzaro, E Gomes-Pires, P Hochedez, O Itani, K Jidar, E Lafont, F Lanternier, O Lortholary, C Louisin, J Lourenco, C Melenotte, P Parize, C Rouzaud, A Serris, F Taieb, J Zeggagh, R Palich, M A Valantin, C Katlama, L Schneider, S Seang, R Tubiana, A Faycal, S Saliba, M Favier, C Aubron, R Agher, Y Dudoit, N Hamani, N Qatib, A Chermak, M Chansombat, G Osseni, D Beniken, A Nadour, N Hall, P Perfezou, J C Duthe, F B Drevillon, J P Talarmin, L Khatchatourian, P Petitgas, F Bani-Sadr, V Brodard, M Hentzien, I Kmiec, D Lambert, D Lebrun, M Moutel, A Brunet, H Marty, Y N’Guyen, C Arvieux, M Baldeyrou, F Benezit, M Cailleaux, J M Chapplain, M Dupont, J C Duthé, S Ismaël, T Jovelin, A Lebot, F Lemaitre, D Luque-Paz, A Maillard, C Morlat, S Patrat-Delon, L Picard, M Poisson-Vannier, C Revest, M Pronier, M Sebillotte, P Tattevin, J Vivent, A Gagneux-Brunon, E Botelho-Nevers, A Pouvaret, F Saunier, V Ronat, A Ursenbach, C Cheneau, C Bernard-Henry, S Fafi-Kremer, P Gantner, C Mélounou, P Klee, Y Hansmann, N Lefebvre, Y Ruch, F Danion, B Hoellinger, T Lemmet, V Gerber, J M Schevin, A Fuchs, C Le Hyaric, D Rey, P Delobel, M Alvarez, N Biezunski, X Boumaza, A Chan Sui Ko, N Collercandy, A Debard, C Delpierre, P Gandia, C Garnier, R Gueneau, L Lelièvre, G Martin-Blondel, C Rastoll, S Raymond, C Vellas, O Robineau, E Aïssi, I Alcaraz, E Alidjinou, V Baclet, A Boucher, V Derdour, B Lafon-Desmurs, A Meybeck, M Pradier, M Tetart, M Valette, N Viget, A Diarra, E Bontemps, G Corvaisier, M Brière, M De La Chapelle, M Gousseff, R Nguyen Van, M Thierry
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W4417296457