LMX1A and APOE ɛ Genotype Associations With Working Memory Training Effects in HIV and Non-HIV
Year: 2025
Type: article
Abstract: BACKGROUND AND OBJECTIVES: ɛ4 genotype variations influenced these effects in individuals with HIV and HIV-seronegative (SN) controls. METHODS: ɛ-rs429358/rs7412. Primary outcomes included near-transfer and far-transfer training gains and genotype associations at 1 and 6 months. Secondary outcomes were genotypic effects on self-reported functioning. Linear mixed-effect models were used to compare the training gains across training types, HIV serostatus, and genotype variations. RESULTS: = 0.008, β = 0.68 [0.14, 1.22] at 1 month, and β = 0.90 [0.25, 1.55] at 6 months). DISCUSSION: ɛ4 carriers. CLASSIFICATION OF EVIDENCE: genotype status. NCT02602418 (registered at ClinicalTrials.gov, Registered: May 11, 2015. First patient enrolled: September 15, 2012.
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,450
OpenAlex ID: W4417297288