Expanding the causes of Fever of Unknown Origin in immunocompromised patients: report of two cases highlighting the role of SARS-CoV-2
Year: 2025
Type: article
Study design: Case Report
Abstract: M ore than 60 years after the first definition by Petersdorf and Beeson, Fever of Unknown Origin (FUO) still remains a diagnostic challenge.The absence of an identified cause of fever, despite reasonable investigations in the in/outpatient context, and the persistence of fever for a sufficient time to rule out self-limiting conditions are the core features of FUO [1,2].Multiple and disparate infectious disease processes are involved into FUO diagnostic workup.Historically, it has been divided into classic, nosocomial, immunodeficiency-related, and travel-associated types: such a classification provides a useful SUMMARY Fever of Unknown Origin (FUO) remains a diagnostic challenge for clinicians, with multiple infectious and non-infectious etiologies.SARS-CoV-2 can determine a prolonged viral shedding in the immunocompromised host, firstly in those receiving B-cell targeted therapies, being responsible of persistent infection which may configure as a FUO.We report two cases of long-last-ing fever in patients with multiple sclerosis and B-cell depletion, finally diagnosed as COVID-19.We suggest the inclusion of SARS-CoV-2 testing in the differential diagnosis of FUO.
Source: Infezioni in Medicina
Institutions: Ospedale Amedeo di Savoia, University of Turin
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4417297613
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