Work

Artificial intelligence-guided personalized ablation improves freedom from atrial arrhythmia in heart failure: A sub-analysis of the TAILORED-AF trial

Year: 2025

Type: article

Abstract: Atrial fibrillation (AF) and heart failure (HF) frequently coexist, creating a complex clinical scenario that amplifies morbidity and worsens prognosis. Catheter ablation emerged as a cornerstone therapy for rhythm control in this population, particularly in patients with reduced ejection fraction1. However, the optimal ablation strategy remains debated, especially in those with advanced HF symptoms. This research letter presents a sub-analysis of the TAILORED-AF trial, which investigated the efficacy of a personalized, dispersion-guided ablation strategy targeting regions of spatiotemporal dispersion (tailored arm) compared to conventional anatomical pulmonary vein isolation (PVI, anatomical arm) in patients with persistent AF2.

Source: Heart Rhythm O2

DOI: 10.1016/j.hroo.2025.12.007