Work

Recent advances in nanomedicine strategies for nervous system injuries biomolecular regeneration

Year: 2025

Type: article

Abstract: Nervous system injuries, encompassing spinal cord injury, peripheral nerve injury, and traumatic brain injury, represent a formidable challenge to global healthcare systems owing to their intricate pathophysiological mechanisms and the inherently restricted regenerative potential of neural tissues. Recent advancements in nanomedicine have opened exciting possibilities for developing novel therapeutic strategies to promote neural repair and regeneration. This review summarizes the recent progress in the application of regenerative nanomedicine for nervous system injury repair, including promoting neurogenesis and axonal growth, modulating inflammation and glial scar formation, delivering anti-inflammatory agents, modulating the immune response, providing structural support and guidance, enabling electrical stimulation and sensing. We critically examine the challenges and prospects within this rapidly advancing field, highlighting the imperative for enhanced biocompatibility, comprehensive long-term safety evaluations, and the innovation of advanced nanomedicine with tailored properties. Notwithstanding these challenges, the integration of nanomedicine into therapeutic strategies offers transformative potential for addressing nervous system injuries, heralding a new era in patient care with the prospect of significantly enhancing functional recovery and quality of life.

Source: Materials & Design

DOI: 10.1016/j.matdes.2025.115333