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Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors

Year: 2025

Type: article

Abstract: We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c04339

Authors: Wenkai Pan, Anastasia Grigoryeva, Corrado Bacchiocchi, Pablo Ballester, Luca Valgimigli, Manuel Petroselli

Institutions: University of Bologna, Università di Camerino, Institució Catalana de Recerca i Estudis Avançats, Institut Català d'Investigació Química, Barcelona Institute of Science and Technology, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Ministerio de Ciencia, Innovación y Universidades, Generalitat de Catalunya, Ministero dell’Istruzione, dell’Università e della Ricerca, Institut Català d'Investigació Química, China Scholarship Council, Agència de Gestió d'Ajuts Universitaris i de Recerca, European Regional Development Fund, NextGenerationEU

Awards: G1067085887, G248039914, G2578815869, G3122536655, G5419776491, G6932828072

OpenAlex ID: W4417304526

FWCI:

Cites: 68

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