Work

Skin and gut microbiome in atopic dermatitis: Mechanisms and therapeutic opportunities

Year: 2025

Type: article

Abstract: The pathogenesis of atopic dermatitis (AD) comprises a combination of genetic, immune, and microbial factors. An imbalance in skin and gut microbiota composition, termed dysbiosis, may contribute to AD pathogenesis and severity through overgrowth of pathogenic microbes and suppression of healthy commensal colonization. These, in turn, promote barrier disruption and pro-inflammatory responses. The skin and gut microbiota composition plays crucial roles in AD, namely as early predictive biomarkers of AD onset; indicators of treatment response; and as future novel therapeutics such as probiotics, fecal, and skin microbiota transplantation. Such interventions aim to directly "reset" and restore a healthy microbial equilibrium, thereby fundamentally repairing barrier function, regulating immune homeostasis, and establishing new adjunctive pathways for the long-term management of AD.

Source: Pediatric Allergy and Immunology

DOI: 10.1111/pai.70265

Authors: Binbin Hou, Huijia Shao, Donglin Yuan, Elizabeth Huiwen Tham

Institutions: National University of Singapore, Dalian Medical University, Second Affiliated Hospital of Dalian Medical University, National University Health System

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,300