Work

Merging Lignin and Glycerol Carbonate Valorization Toward the Green Synthesis of β ‐Adrenergic Blocker Esmolol

Year: 2025

Type: article

Abstract: Producing nitrogen‐containing chemicals through the direct combination of by‐products readily available from agricultural waste, including renewable aromatic building blocks from lignin, is a highly attractive approach for sustainable biorefining processes. Here, we describe a novel synthetic/catalytic route toward the production of the highly valuable β ‐adrenergic blocker esmolol. Our strategy consists of: 1) Reductive Catalytic Fractionation (RCF) of sugarcane lignocellulose mediated by copper porous metal oxides (Cu 20 PMO) in MeOH, leading to the in situ formation of methyl 3‐(4‐hydroxyphenyl) propionate ( 1H ) with good selectivity (>70%), followed by 2) the selective catalytic amination of glycerol carbonate ( GlyC ) with isopropyl amine via the borrowing hydrogen strategy, and 3) the subsequent utilization of the obtained amine intermediate as a phenol alkylating agent in combination with 1H to afford the desired β ‐adrenergic blocker esmolol ( 1Ha ).

Source: ChemSusChem

DOI: 10.1002/cssc.202501540

Authors: Antonio A. Castillo‐Garcia, Katalin Barta

Institution: University of Graz

Language: English

Topic: Lignin and Wood Chemistry

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $4,550