Work

GRK4 R65L causes salt-sensitive hypertension by augmenting renal Hao2-mediated oxidative stress via increasing the phosphorylation of TPI1 and promoting H3K27ac expression

Year: 2025

Type: article

Source: Free Radical Biology and Medicine

DOI: 10.1016/j.freeradbiomed.2025.12.017

Authors: Fuwei Zhang, Jindong Wan, Lianghong Jiang, Xiaoqian Lin, Lin Chen, Muqing Shao, Jiayao Chen, Luning Wang, Shuo Zheng, Hongmei Ren, Caiyu Chen, Pedro A. Jose, Chunyu Zeng, Jian Yang

Institutions: Chongqing Medical University, First Affiliated Hospital of Chengdu Medical College, Army Medical University, Southwest Medical University, Daping Hospital, George Washington University

Language: English

Topic: Blood Pressure and Hypertension Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Foundation for the National Institutes of Health, National Natural Science Foundation of China, Chongqing Medical University, Natural Science Foundation of Chongqing, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Studio

Awards: G1290669167, G1412447309, Molecular Mechanisms in Salt Sensitivity of Blood Pressure, G3945615413, G4320112092, Renal dopamine-1 receptor defect in hypertension, G78718136, G9000240202, G9000252517

OpenAlex ID: W4417333338

FWCI:

Cites: 50

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