Work

Primary intracerebral Ewing sarcoma featuring curvilinear calcification: a case report

Year: 2025

Type: article

Abstract: Ewing sarcoma (EWS) is a highly aggressive malignant tumor that primarily affects bones and soft tissues, with primary intracerebral cases being exceptionally rare. While sporadic cases have been reported, a systematic analysis of their radiological features—particularly calcification patterns—is lacking. We present what we believe to be the first case of a right parieto-occipital EWS exhibiting characteristic curvilinear calcification. A comparative review of 8 intracerebral EWS cases revealed that while cystic changes are common (75 %), curvilinear calcification is unique, and marked enhancement is a consistent finding. Our patient was treated with craniotomy, VDC/IE chemotherapy, and IMRT, and achieved no evidence of disease at 12-month follow-up. This systematic contextualization highlights that curvilinear calcification is a novel diagnostic clue for intracerebral EWS, which generally has a favorable outcome with multimodal therapy.

Source: Interdisciplinary Neurosurgery

DOI: 10.1016/j.inat.2025.102166

Authors: Xiujiao Wei, Jimei Meng, Qinghong Duan

Institutions: Guiyang Medical University, Guizhou Cancer Hospital, Affiliated Hospital of Guizhou Medical University

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,910