Work

Metformin in Diabetes Management and Immune Modulation: A Comprehensive Review

Year: 2025

Type: article

Abstract: Metformin is a primary treatment for type 2 diabetes (T2D), well-known for its ability to lower blood glucose levels through both AMP-activated protein kinase (AMPK)-dependent and -independent pathways. Recent evidence suggests that metformin also possesses immunomodulatory properties, indicating its potential as a therapeutic agent that extends beyond metabolic regulation. This review summarizes the current understanding of metformin's dual roles in managing diabetes and modulating the immune system. It also explores the underlying mechanisms, clinical implications, and potential directions for future research.

Source: Iranian Journal of Allergy Asthma and Immunology

DOI: 10.18502/ijaai.v25i1.20431

Authors: Mehrangiz Ghafari, Javad Poursamimi, Foroogh Asli

Institution: Zabol University of Medical Sciences

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $300