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Synthesis of enantiomerically enriched β- N -amino ( S )-α-alanine analogs via sequential reactions on a chiral Ni( ii ) complex

Year: 2025

Type: article

Abstract: A chiral Ni( ii )-complex platform enables the efficient synthesis of enantioenriched β- N -Amino ( S )-α-alanine analogs via Michael addition of propargylamine derivatives to a dehydroalanine moiety and subsequent modification of the alkyne fragment.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob01593f

Authors: Emma A. Khachatryan, Lala A. Stepanyan, Hasmik R. Gevorgyan, Armen S. Sargsyan, Anahit M. Hovhannisyan, Anna F. Mkrtchyan, Andrei V. Malkov, Ashot S. Saghyan

Institutions: Yerevan State University, Scientific and Production Center “Armbiotechnology” NAS RA, National Academy of Sciences of Armenia, A. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, Loughborough University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

OpenAlex ID: W4417362083

FWCI: 0.297

Cites: 43

Cited by: 1

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