Work

From Patient‐Specific Hemodynamic Modeling to Clinical Decision‐Making in Chronic Thromboembolic Pulmonary Hypertension: Opportunities and Caveats

Year: 2025

Type: article

Abstract: We read with great interest the recent article on patient-specific hemodynamic modeling to estimate microvascular disease burden and predict response to pulmonary endarterectomy (PEA) in chronic thromboembolic pulmonary hypertension (CTEPH) [1].The integration of multiscale structure-based modeling with routine clinical data addresses the key challenges of quantifying distal microvascular remodeling and anticipating heterogeneous hemodynamic responses after technically successful PEA.The strong correlation between modeled and observed changes in mean pulmonary artery pressure (mPAP), together with the use of CT pulmonary angiography-derived vascular geometry and a continuous remodeling scale, is particularly compelling.In parallel, histopathological data describing heterogeneous endothelial features and angiogenic cues along the pulmonary vascular tree in CTEPH further reinforce the biological plausibility of regionally explicit modeling strategies [2].

Source: Pulmonary Circulation

DOI: 10.1002/pul2.70224

Authors: Gianluca Pagnoni, Aurora Vicenzi, Francesca Coppi

Institutions: Guglielmo da Saliceto Hospital, Istituto Nazionale per le Ricerche Cardiovascolari, University of Modena and Reggio Emilia

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,310