Work

Quantra® Viscoelastic Testing in Pediatric Trauma: A Review of Emerging Evidence and Clinical Integration

Year: 2025

Type: article

Abstract: Early recognition and correction of trauma-induced coagulopathy (TIC) are critical determinants of survival in pediatric trauma. Traditional laboratory evaluations, such as prothrombin time (PT)/international normalised ratio (INR) and fibrinogen, provide a delayed and incomplete assessment of real-time clotting behavior. The Quantra® System (HemoSonics, Charlottesville, VA, USA), a type of viscoelastic hemostatic assay (VHAs), utilizes soundwave technology to provide a more rapid and comprehensive assessment of coagulation. This review summarizes current evidence regarding Quantra use in pediatric trauma, compares it with conventional viscoelastic tools (TEG® (Haemonetics, Boston, MA, USA) and ROTEM® (Werfen, Bedford, MA, USA)), and discusses emerging experience in perioperative monitoring and trauma resuscitation pathways. Though preliminary data suggests Quantra is well-correlated with conventional VHAs and offers rapid, simple, and standardized assessment in pediatric trauma resuscitation, large-scale pediatric validation studies are needed to define thresholds, optimize transfusion algorithms, and assess outcomes.

Source: Cureus

DOI: 10.7759/cureus.99134