The assessment for potential thyroid‐mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology
Year: 2025
Type: article
Abstract: ) are used as the model species to assess potential endocrine-disrupting properties in non-mammalian species through thyroid modality. The amphibian metamorphosis assay is the most frequently available test. Attempts have been made to modify this protocol in order to make it more fit for purpose and overcome potential limitations. In light of these developments, EFSA, with the support of the Working Group on Endocrine Disruptors, under the auspices of a self-task mandate here endeavours to clarify the pros and cons of newly proposed amphibian protocols when compared with the standard guideline tests. Moreover, recommendations to facilitate the interpretation of findings in relation to changes in thyroid histopathology have been included.
Source: EFSA Journal
Authors: European Food Safety Authority (EFSA), Lisa Baumann, Alice Baynes, Susanne Hougaard Bennekou, Kevin Crofton, Zhichao Dang, Sigmund Degitz, Jean‐Baptiste Fini, Mary Gilbert, Henrik Holbech, Andrea Terron, Majorie Van Duursen, Emily McVey, Maria Arena, Aude Kienzler, Simone Rizzuto, Laura Villamar Bouza, Martin Wilks
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,400
OpenAlex ID: W4417362328