Supporting efficacy and scaling with a next-generation T cell AOF formulation medium
Year: 2024
Type: article
Abstract: Cell culture media are critical to successful cell therapy production, serving as a source of essential nutrients and maintaining the physiological conditions necessary for optimal cell growth and function. The use of well-defined, animal origin-free (AOF) media is increasingly recognized as being pivotal in ensuring experimental reproducibility, minimizing contamination risks, and addressing stringent regulatory requirements. This article explores the CTS™ OpTmizer™ One serum-free medium, an innovative AOF formulation tailored for T cell expansion. This medium is designed to enhance the early memory T cell phenotype, improve cell viability, and facilitate scalability, positioning it as a crucial tool for both preclinical research and clinical manufacturing.
Source: Cell and Gene Therapy Insights
Authors: Alan Gutowski, Joanna Kern
Institution: Thermo Fisher Scientific (United States)
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4417365272