Work

Brain death versus circulatory death: how functional warm ischemia and cold storage impact myocardial membrane repair in human donor hearts

Year: 2025

Type: article

Abstract: This study demonstrates that donor hearts procured after circulatory death (DCD) exhibit early Annexin A1 depletion and activation of the NLRP3/caspase-1/GSDMD-mediated pyroptosis pathway during cold storage-a phenomenon absent in brain-dead (DBD) donors. We establish a direct correlation between warm ischemia time and pyroptotic damage in DCD hearts. These findings highlight Annexin A1 as a crucial mediator of ischemic injury, offering a promising therapeutic target to enhance viability in DCD donor hearts.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00705.2025

Authors: Shiyi Li, Rishav Bhattacharya, Abdussalam E. Elsenousi, Katherine V. Nordick, Adel M. Hassan, Syed B. Peer, Camila Hochman-Mendez, Todd K. Rosengart, Kenneth K. Liao, Nandan K. Mondal

Institution: Baylor College of Medicine

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4417411489

FWCI: 0.892

Cites: 28

Cited by: 1

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