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Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency

Year: 2025

Type: article

Abstract: This study reports that a loss-of-function G6PD variant exacerbates BLM-induced lung fibrosis in rats by suppressing polyamine pathway and increasing oxidative stress that oxidized the key ECM-related proteins and antioxidants.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00193.2025

Authors: Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Angelo D’Alessandro, Yongho Bae, Sachin A. Gupte

Institutions: New York Medical College, University at Buffalo, State University of New York, University of Colorado Anschutz

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Heart, Lung, and Blood Institute

Awards: G147872411, G3123249089, G3439456981

OpenAlex ID: W4417412367

FWCI:

Cites: 62

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