Comparative cost analysis of a diagnostic multi-omics platform for decision support in advanced cancer – results from the Tumor Profiler Melanoma project
Year: 2025
Type: article
Study design: Observational Study
Abstract: While advances in the understanding of tumor biology through multi-omics profiling hold the promise of substantially improving patient outcomes, the cost implications of such strategies remain unclear. We therefore performed a comparative cost analysis of patients treated either within the Tumor Profiler (TuPro) melanoma project or from a control cohort who received treatment after standard next-generation sequencing testing. After adjustment of cohorts through inverse probability of treatment weighting, we found no evidence of statistically significant differences in total costs between the two cohorts (95% confidence interval -10% to +67%). Importantly, treatment costs (95% confidence interval -28% to +41%) were similar between the two cohorts. In conclusion, we found no evidence that treatment recommendations guided by advanced multi-omics profiling led to significantly higher treatment costs in a Swiss context.
Source: npj Precision Oncology
Authors: Tarun Mehra, Dominik Menges, Benedict Gosztonyi, Nicola Miglino, Alexander Ring, Laura Boos, Bettina Sobottka, Rudolf Aebersold, Melike Ak, Faisal S. Al-Quaddoomi, Silvana I. Albert, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per-Olof Attinger, Marina Bacac, Monica-Andreea Baciu-Drăgan, Daniel Baumhoer, Beatrice Beck-Schimmer, Niko Beerenwinkel, Christian Beisel, Lara Bernasconi, Anne Bertolini, Bernd Bodenmiller, Ximena Bonilla, Lars Bosshard, Byron Calgua, Ruben Casanova, Stéphane Chevrier, Natalia Chicherova, Ricardo Coelho, Maya D’Costa, Esther Danenberg, Natalie R. Davidson, Reinhard Dummer, Stefanie Engler, Martin Erkens, Katja Eschbach, Cinzia Esposito, André Fedier, Pedro F. Ferreira, Joanna Ficek-Pascual, Anja L. Frei, Bruno Frey, Sandra Goetze, Linda Grob, Gabriele Gut, Detlef Günther, Pirmin Haeuptle, Viola Heinzelmann-Schwarz, Sylvia Herter, Rene Holtackers, Tamara Huesser, Alexander Immer, Anja Irmisch, Francis Jacob, Andrea Jacobs, Tim M. Jaeger, Alva R. James, Philip M. Jermann, André Kahles, Abdullah Kahraman, Viktor H. Koelzer, Werner Kuebler, Jack Kuipers, Christian P. Kunze, Christian Kurzeder, Kjong-Van Lehmann, Mitchell Levesque, Ulrike Lischetti, Flavio C. Lombardo, Sebastian Lugert, Gerd Maass, Markus G. Manz, Philipp Markolin, Martin Mehnert, Julien Mena, Julian M. Metzler, Nicola Miglino, Emanuela S. Milani, Holger Moch, Simone Muenst, Riccardo Murri, Charlotte KY Ng, Stefan Nicolet, Marta Nowak, Monica Nunez Lopéz, Patrick GA Pedrioli, Lucas Pelkmans, Salvatore Piscuoglio, Michael Prummer, Laurie Prélot, Natalie Rimmer, Mathilde Ritter, Christian Rommel, María L. Rosano-González, Gunnar Rätsch, Natascha Santacroce, Jacobo Sarabia del Castillo, Ramona Schlenker, Petra C. Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Wenguang Shao, Franziska Singer, Sujana Sivapatham, Berend Snijder, Bettina Sobottka, Vipin T. Sreedharan, Stefan Stark, Daniel J. Stekhoven, Tanmay Tanna, Alexandre PA Theocharides, Tinu M. Thomas, Markus Tolnay, Vinko Tosevski, Mustafa A. Tuncel, Marina Tusup, Audrey Van Drogen, Marcus Vetter, Tatjana Vlajnic, Sandra Weber, Walter P. Weber, Rebekka Wegmann, Michael Weller, Fabian Wendt, Norbert Wey, Andreas Wicki, Mattheus HE Wildschut, Bernd Wollscheid, Shuqing Yu, Johanna Ziegler, Marc Zimmermann, Martin Zoche, Gregor Zuend, Viktor Hendrik Koelzer, Holger Moch, Nora C. Toussaint, Mitchell Levesque, Egle Ramelyte, Johanna Mangana, Reinhard Dummer, Andreas Wicki
Institutions: University of Zurich, University Hospital Zurich, Karolinska Institutet, University Hospital of Basel, ETH Zurich, Institute for Molecular Systems Biology, SIB Swiss Institute of Bioinformatics, Swiss Data Science Center, NEXUS Personalized Health Technologies, Kantonsspital Aarau, Institute for Machine Learning, Roche (Switzerland), Institute of Molecular Health Sciences, University of Basel, Life Science Zurich, Kantonsspital Baselland, FHNW University of Applied Sciences and Arts Northwestern Switzerland, Universitätsklinikum Aachen, University Hospital Cologne, RWTH Aachen University, University of Bern
Language: English
Subfield: Economics and Econometrics
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $4,090
OpenAlex ID: W4417413249