Work

Enhancing liver regeneration prior to resection: A review of embolic materials utilized in portal vein embolization

Year: 2025

Type: article

Abstract: Portal vein embolization (PVE) plays a pivotal role in the management of liver tumors, as it selectively interrupts the portal vein's branches to stimulate the expansion of the Future Liver Remnant (FLR), consequently mitigating the risks of postoperative hepatic insufficiency and hepatic failure. This analysis meticulously examines the properties, clinical applications, and their influence on FLR growth for a spectrum of embolic agents, including n-butyl cyanoacrylate (NBCA) glue, polyvinyl alcohol (PVA) particles, ethanol, gelatin sponge, ethiodized oil, fibrin sealant, central vascular plugs and coils, and sclerosants. Moreover, the review delves into the safety profile of PVE embolic materials, underscoring that while PVE is generally deemed secure, there is a necessity to remain cautious about potential adverse events, such as unintended embolization and post-embolization syndrome. The horizon for future research is set to encompass the innovation of novel embolic agents, the synergy of PVE with additional therapeutic approaches, and the resolution of challenges inherent in PVE studies. Ultimately, this review serves as a scientific reference for medical practitioners in their quest to identify the most suitable embolic materials for PVE, while underscoring the paramountcy of ongoing research in bolstering the procedure's safety and efficacy.

Source: Asian Journal of Surgery

DOI: 10.1016/j.asjsur.2025.10.028

Authors: Boyang Wu, Yuewei Zhang

Institutions: Beijing Tsinghua Chang Gung Hospital, Tsinghua University

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200