Year: 2025
Type: article
Abstract: Introduction: Management of IDH-mutant lower-grade gliomas (IDHm LGGs) is complex, requiring careful balance between tumor control as well as neurocognitive function and quality of life. While multidisciplinary clinics improve outcomes in other cancers, no structured model exists for IDHm LGGs. Methods: We present a framework for a multidisciplinary clinic a dedicated to patients with IDHm LGGs. Discussion: IDHm LGGs, including WHO grade 2 astrocytomas and oligodendrogliomas, affect younger adults with median survivals exceeding a decade. Tumor related seizures are a significant source of distress for patients with IDHm LGGs, in addition to burden of disease. Treatment decisions such as surgery, medical therapy, and radiation, along with seizure management are highly individualized and benefit from coordinated, longitudinal care. A dedicated multidisciplinary LGG clinic integrates expertise across neurosurgery, neuro-oncology, epilepsy, and neuropsychology to optimize outcomes and patient experience to create a onco-functional balance. Conclusion: A multidisciplinary clinic dedicated to IDHm LGGs can provide a collaborative model for comprehensive, patient-centered care for a rare and complex disease which may be replicated at other brain tumor centers.
Source: Frontiers in Oncology
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Northwestern University
OpenAlex ID: W4417415180