Work

Admission monocyte-to-albumin ratio predicts 3-month functional outcomes after acute ischemic stroke: a retrospective cohort study

Year: 2025

Type: article

Abstract: Background: The monocyte-to-albumin ratio (MAR) integrates systemic inflammation and nutritional status derived from routine laboratory data. We assessed whether the admission MAR is associated with 3-month functional outcomes following acute ischemic stroke (AIS). Methods: We conducted a single-center, retrospective cohort study of consecutive adults with AIS admitted within 3 days of symptom onset (October 2023-March 2024). MAR was calculated from the admission monocyte counts and serum albumin levels. The primary outcome was poor 3-month functional status, defined as a modified Rankin Scale (mRS) score ≥3. Associations between MAR and outcomes were examined using multivariable logistic regression (with and without adjustment), smooth curve fitting, and prespecified subgroup analyses (sex, age, smoking status, drinking status, hypertension, diabetes status, eGFR, and TOAST subtype). Results: > 0.05). With respect to the TOAST subtype, the MAR remained significant for large-artery atherosclerosis (OR 1.10; 95% CI 1.02-1.20) and small-artery occlusion (OR 1.23; 95% CI 1.07-1.42), but not for cardioembolism. Conclusion: The admission MAR is independently and positively associated with poor 3-month functional outcomes after AIS. MAR is a promising tool for early risk assessment when it is integrated with established predictors.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1705544

Authors: Huizhen Lu, Chuanliu Wang, Ming Yang, Yuanshao Lin, Weifeng Jiang

Institutions: Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Quzhou City People's Hospital

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801