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Computational and experimental analysis for the mismatched DNA recognition mechanism of TaqMutS

Year: 2026
Type: article
Abstract: By sensing local conformational strains in DNA, Taq MutS utilizes a push-pull mechanism via the synergy of residues S57 and D472 to modulate π-stacking interactions between the key recognition residue F39 and DNA, thereby achieving specific mismatch-site recognition. Meanwhile, residues K61 and R473 fine-tune non-specific binding of Taq MutS through electrostatic synergy.
DOI: 10.1016/j.synbio.2026.10.011
Authors: Wenyan Jiang, Yiyang Ding, Haojie Sun, Yuxuan Li, Xiao Liang, Quanshun Li
Institution: Jilin University
Language: English
Open Access status: gold
Estimated APC paid: $1,500
Funders: Jilin Province Development and Reform Commission, Royal Society, Royal Society of Chemistry, National Natural Science Foundation of China, China Postdoctoral Science Foundation, People's Government of Jilin Province, National Key Research and Development Program of China
Awards: G2025148830, G4574427219, G5676526665, G6394399298, G7019178536, G975092767
OpenAlex ID: W4417415430
FWCI:
Cites: 18
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Related to: 10