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A case report of neoadjuvant targeted therapy in stage IIIA non-small cell lung cancer with BRAF V600E mutation

Year: 2025

Type: article

Abstract: For advanced or metastatic non-small cell lung cancer (NSCLC) with actionable gene mutations, first-line targeted therapy significantly prolongs survival compared to chemotherapy and immunotherapy. Perioperative targeted therapy has achieved significant improvement in early- and locally advanced-stage NSCLC patients with epidermal growth factor receptor ( EGFR ) and anaplastic lymphoma kinase ( ALK ) mutations. However, there have been few reports of neoadjuvant treatment in patients with non-small cell lung cancer with rare mutations, such as BRAF (V-Raf murine sarcoma viral oncogene homolog B) V600E mutation. In this report, we present a case of inoperable stage IIIA lung adenocarcinoma with a BRAF V600E mutation that underwent radical lung cancer surgery following neoadjuvant targeted therapy. The postoperative pathology review revealed a pathological complete response (pCR). This case illustrates that BRAF and mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor therapy may represent a viable option for neoadjuvant therapy in locally advanced BRAF V600E mutant NSCLC.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1664182