Work

In situ released bacterial membrane vesicles activate the STING pathway via boosting the intracellular DNA pool for immunotherapy

Year: 2025

Type: article

Abstract: peroxidase (POD)-like activity, collectively augments the DNA pool within tumors, fostering the activation of the STING signaling pathway. This work offers a paradigm for the design of a nanoplatform to stimulate the STING signaling pathway by enhancing the DNA pool for immunotherapy.

Source: Chemical Science

DOI: 10.1039/d5sc07867a

Authors: Wenjie Wang, Anjun Song, Fang Pu, Yanjie Zhang, Jinsong Ren, Xiaogang Qu

Institutions: University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Rare Earth Resources Utilization

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China