Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Ageing involves heterogeneous brain grey matter (GM) patterns that may overlap with dementia-related changes. We evaluated cognitively unimpaired older adults to identify specific GM patterns, their clinical and cognitive profiles, and longitudinal trajectories. Methods We analysed 746 participants from the Gothenburg H70 study using random forest cross-sectional clustering based on MRI measures of cortical thickness and subcortical volume across 41 regions. Using regression-based models, we examined associations with clinical, MRI variables, biochemical, and CSF Alzheimer biomarkers ( n = 286) and assessed 5-year longitudinal cognitive and brain trajectories. Results Five clusters emerged, mainly differing in frontoparietal regions. Compared to Cluster 1 (reference), Cluster 2 showed diffuse GM loss, higher odds of diabetes ( OR = 2.54, 95% CI [1.27–5.06]) and at-risk alcohol consumption ( OR = 1.83, 95% CI [1.13–2.97]), poorer episodic memory ( β = − 0.19, p = 0.014) and visuospatial abilities ( β = − 0.21, p = 0.044), and greater longitudinal decline in MMSE ( β slope = − 0.45, p = 0.035) and increase in white matter hyperintensity volume ( β slope = 1.84, p = 0.004). Cluster 3 showed thicker GM and lower BMI ( OR = 0.57, 95% CI [0.35–0.94]). Cluster 4 had preserved GM, lower smoking habits ( OR = 0.62, 95% CI [0.40–0.95]), triglyceride levels ( OR = 0.55, 95% CI [0.32–0.95]) and depression ( OR = 0.17, 95% CI [0.05–0.56]), higher education ( OR = 2.52, 95% CI [1.08–5.87]), and better cognition in multiple domains. Cluster 5 had a mixed GM pattern and higher odds of heart disease ( OR = 3.44, 95% CI [1.48–8.01]). Conclusions Cardiovascular and psychosocial factors influence GM integrity, which in turn relates to cognition. Targeting these risk factors may preserve brain health in late life.
Source: BMC Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: Eli Lilly and Company, Biogen, Åke Wiberg Stiftelse, Gun och Bertil Stohnes Stiftelse, Parkinson's Foundation, European Commission, Stiftelsen Handlanden Hjalmar Svenssons, Svenska Sällskapet för Medicinsk Forskning, Hjärnfonden, Karolinska Institutet, Stockholms Läns Landsting, Vetenskapsrådet, Stiftelsen Lars Hiertas Minne, Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Stiftelsen Psykiatriska Forskningsfonden, Alzheimerfonden, Demensfonden, Parkinsonfonden, HORIZON EUROPE Framework Programme, Center for Innovative Medicine
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OpenAlex ID: W4417419892