Work

Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors

Year: 2025

Type: article

Abstract: efficacy of anti-mouse CLDN18.2 CAR-T against S6M cells by recruiting NK cells to tumor microenvironment, suggesting the potential utility of our novel syngeneic gastric cancer cell line model in designing innovative clinical therapeutic approaches.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2025.201120

Authors: Min-Jung Seo, Jin Hue Jeong, Han Na Park, In-Pyo Baek, Jun Won Park, Seo Young Kim, Yu Ri Choi, Seulki Choi, Seung Min Ham, Dongmin Park, Hye-Ran Kim, Ho Kyung Seo, Hark Kyun Kim

Institutions: National Cancer Center, Soongsil University, Seoul National University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: National Cancer Center, Ministry of Food and Drug Safety, National Cancer Center

Awards: G2208315554, G6049121839, G6453633174, G7564730016, G789325297, G923498535

OpenAlex ID: W4417419936

FWCI:

Cites: 50

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