Work

Verbal versus Nonverbal Processing Leads to Generalized Hemispheric Laterality Effects that Span Multiple Networks

Year: 2025

Type: preprint

Abstract: Precision neuroimaging was used to explore specialization for verbal versus nonverbal processing. Consistent with prior findings, individuals exhibited a spatially left-lateralized association language network, with regions in both hemispheres robustly responding to processing of meaning-based sentences. We next examined differential responses to verbal (words) versus nonverbal (faces) materials within the same working memory task. The right hemisphere components of the language network responded more strongly to nonverbal than to verbal materials, splitting the network's functional profile between the hemispheres. Similar patterns were observed across multiple association networks including putative cognitive-control, action-mode, and attention networks. The hemispheric laterality effect was prospectively replicated in a second independent study. These findings highlight a generalized laterality phenomenon that transcends individual specialized networks and aligns with a broad mechanism that modulates processing between the hemispheres.

Source: eLife

DOI: 10.64898/2025.12.15.694432

Authors: Wendy Sun, Lauren M. DiNicola, Randy L. Buckner

Institutions: Harvard University, University of Virginia, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging

Language: English

Topic: Hemispheric Asymmetry in Neuroscience

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500