Work

Colloidal Chemistry and Nanostructure Engineering of Gold Nanorods for Glioblastoma Applications

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide This study focuses on the synthesis and characterization of AuNRs optimized for glioblastoma treatment. Using controlled chemical processes, AuNRs with precise size and morphology were synthesized and characterized via dynamic light scattering and transmission electron microscopy. Cytotoxicity assays on glioblastoma (U87MG) and normal (HaCaT) cell lines evaluated their biocompatibility and selective cytotoxicity. Fluorescence microscopy and flow cytometry analyses revealed efficient cellular uptake via endocytosis, supporting their potential for targeted therapy. The results highlight AuNRs as a promising nanoplatform for overcoming key challenges in glioblastoma treatment, including selective tumor targeting and BBB penetration. This research advances precision medicine and underscores the transformative role of nanotechnology in developing next-generation glioblastoma therapies.

Source: ACS Omega

DOI: 10.1021/acsomega.5c09136

Authors: Sofia-Maria Gratsia, Ioannis Maris, Evangelia Tsitsou, Elias Sakellis, Nikos Boukos, Eleni K. Efthimiadou

Institutions: National and Kapodistrian University of Athens, National Centre of Scientific Research "Demokritos", Institute of Nanoscience and Nanotechnology

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935