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Characterizing growth and early hemodynamic inefficiencies: Phase-contrast magnetic resonance imaging analysis of the aorta in post-Fontan hypoplastic left heart syndrome

Year: 2025

Type: article

Study design: Observational Study

Abstract: Objective: To address the lack of routine hemodynamic assessment during aortic reconstruction in patients with hypoplastic left heart syndrome (HLHS) with a momentum-based metric from phase-contrast magnetic resonance imaging (MRI) data (4D Flow). Methods: ). Results: = .022) despite the absence of anatomic obstruction and an average growth trajectory in line with that of controls. Conclusions: and outcomes.

Source: JTCVS structural and endovascular.

DOI: 10.1016/j.xjse.2025.100086

Authors: Joao Filipe Fernandes, Hannah Bellsham-Revell, Prenali Dwisthi Sattwika, Mahta Ghahfarokhi, Hui Yann Yap, Anna Kiely, Xabier Morales Ferez, Oscar Camara, Julio Sotelo, James Wong, David Barron, Caner Salih, Kuberan Pushparajah, Adam J. Lewandowski, Pablo Lamata, Adelaide de Vecchi

Institutions: King's College London, St Thomas' Hospital, Evelina London Children's Healthcare, Universitas Gadjah Mada, University of Oxford, Universitat Pompeu Fabra, Universidad Técnica Federico Santa María

Language: English

Topic: Congenital Heart Disease Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Wellcome Trust, Action Medical Research, Additional Ventures, National Institute for Health and Care Research, British Heart Foundation, Monash University, Agencia Nacional de Investigación y Desarrollo, Centre For Medical Engineering, King’s College London

Awards: G1804026734, G2318397746, Cardiac remodelling in preterm-born offspring: defining the importance of early postnatal changes and potential for neonatal dietary interventions to reduce long-term risk, Unravelling the physics of the pressure drop in blood flow constrictions, G961285871

OpenAlex ID: W4417427180

FWCI:

Cites: 30

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