Work

Anti-Inflammatory and Anticancer Potential of Solanum tuberosum L. Bioactive with Proposed Mechanisms in Oral Squamous Cell Carcinoma: A Scoping Review

Year: 2025

Type: article

Abstract: : Solanum tuberosum L. (potato) contains various bioactive compounds with health-promoting properties. Its extracts are composed of multiple classes of phytochemicals, among which two are of particular interest, anthocyanins, a subclass of polyphenols, and steroidal glycoalkaloids. The predominant glycoalkaloids, α-solanine and α-chaconine, along with anthocyanins, exhibit potent antioxidant, anti-inflammatory, and anticancer activities. Both α-solanine and α-chaconine have demonstrated pro-apoptotic, anti-proliferative, and anti-inflammatory effects in various cancer models. These compounds have been shown to modulate inflammation-associated pathways implicated in carcinogenesis. However, their relevance to inflammation-driven oral malignancies, particularly oral squamous cell carcinoma (OSCC), remains unclear. This scoping review followed PRISMA-ScR guidelines. A systematic search of PubMed and Scopus was conducted for articles published up to December 2024 using predefined keywords. Eligible studies investigated the anticancer or anti-inflammatory effects of glycoalkaloids or anthocyanins from S. tuberosum in vitro or in vivo. Eighteen studies met the inclusion criteria: 12 in vitro, 2 in vivo, and 4 combining both. Most studies focused on colorectal (n = 6), breast (n = 4), and lung (n = 3) cancers. Treatments with glycoalkaloids (1– 50 μM) or anthocyanins (10– 200 μg/mL) demonstrated pro-apoptotic, anti-proliferative, and anti-angiogenic effects. However, no study evaluated these compounds in OSCC models. Glycoalkaloids and anthocyanins from S. tuberosum exhibit promising anticancer and anti-inflammatory properties in various types of cancer. The absence of OSCC-focused research highlights a significant gap and the need for future studies in this context. Keywords: anticancer, anthocyanins, glycoalkaloids, oral squamous cell carcinoma, Solanum tuberosum L

Source: Journal of Inflammation Research

DOI: 10.2147/jir.s542826

Authors: Lelly Andayasari, Achmad Shidiq, Irna Sufiawati

Institutions: National Research and Innovation Agency, Padjadjaran University

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836