Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND/OBJECTIVES: Cutaneous manifestations of Waldenstrom's macroglobulinaemia (WM), a rare B-cell lymphoproliferative disorder, present a diagnostic challenge. The intent of this article is to raise awareness to clinicians of a potentially overlooked condition, particularly in the context of patients with a monoclonal IgM paraproteinaemia, but also to describe the diagnostic complexity of the disease from a clinicopathological perspective. METHODS: We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM. RESULTS: Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non-tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression. CONCLUSION: The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia.
DOI: 10.1111/ajd.70021
Authors: Monica Narula, Patrick D. Mahar, Edwin Wee Hian Tan, Naveen Singh, Stephen Lade, Henry Miles Prince, Christopher McCormack
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4417428568