LDCT-based lung cancer screening and small cell lung cancer: Limited but non-negligible impact on survival. A brief report
Year: 2025
Type: article
Abstract: Introduction: Low-dose computed tomography (LDCT)-based lung cancer screening (LCS) seems to have very limited impact on small cell lung cancer (SCLC) outcomes. This study aims at describing frequency and outcomes of SCLC in a large LCS population. Methods: Patients with a histological diagnosis of SCLC among the participants of 3 different trials (7473) were selected for the analysis. Demographic and clinical data were collected at the baseline and follow-up screening rounds, while the vital status and date of death were obtained through a dedicated national platform. Results: Of the 396 diagnosed LCs, 28 (7.1%) were SCLCs; median survival time from the diagnosis was 1.5 years, and overall mortality was 71.4%. Screen-detected SCLCs were 20/28 (71.4%); 5/20 (25%) were prevalent cancers and 15/20 (75%) incident ones. Five-year mortality among the screen-detected and non-screen detected SCLCs was 70% and 62.5%, respectively. Conclusion: The frequency of SCLC was lower as compared to other trials. Although no significant differences in 5-year mortality were observed between screen-detected and non-screen-detected SCLCs, the overall 5-year mortality was substantially lower than that reported in non-LCS populations, suggesting that LDCT-based LCS has an impact on SCLC outcome, albeit limited.
Source: Tumori Journal
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,150
Awards: G1378156997, G187812604, G2106689379, G2186909248, G2556692517, G2636645585, G2696953833, G2736236446, G3115756612, G3273369547, G3945503650, G4201605383, G4458958805, G4616009775, G5000000976, G5918134238, Efficacia dell'analisi proteomica sul plasma associata a tac spirale +/- pet nella diagnosi precoce del ca polmonare in soggetti ad alto rischio, G801137187, G8470445483, G8966479081
OpenAlex ID: W4417428891