Year: 2025
Type: article
Study design: Observational Study
Abstract: Early-life exposure to colibactin-producing pks + gut bacteria is hypothesized to imprint mutations on the colorectal epithelium, increasing the risk of colorectal cancer later in life. We demonstrate an extremely high prevalence of pks+ bacteria (>50% of infants) during the first two years of life, suggesting carriage is likely normal during early-life microbiome development. Further research is needed into the conditions in which carriage can lead to mutagenesis.
Source: Gut Microbes
Authors: Shira Levy, Kathryn E. McCauley, Rachel Strength, Emily S. Robbins, Qing Chen, Sivaranjani Namasivyam, George Maxwell, Suchitra K. Hourigan
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,060
Funders: U.S. Department of Health and Human Services, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NHLBI Division of Intramural Research
OpenAlex ID: W4417433665